Ruminations of a Taco-Obsessed Philly Native

In the past, many people believed that aging was a functional decline resulting from molecular damage that could not be prevented. The recent hyper function theory has described aging as a continuation of growth, controlled by signaling pathways like TOR (Target of Rapamycin). According to Mikhail Blagoklonny’s the TOR centric model, rapamycin, alongside other rapalogs, can be used for the treatment of aging and the prevention of diseases. When used in proper schedules and doses, rapamycin can extend the human life span. Although this theory was formerly ridiculed by anonymous peer reviewers and opponents, it is slowly being accepted.

A Critical Review Of Rapamycin

According to the hyperfunctional theory, rapalogs have calorie restriction side effects. For example, the drug has been seen to increase lipolysis and thus imitates fasting. In some cases, rapamycin can lead to starvation diabetes and in other cases; it can lead to starvation like symptoms.

How Will People Die If Aging is Abolished?

Currently, animals and humans die due to age-related diseases manifested by aging. By slowing down aging, rapamycin delays age-related diseases such as cancer. Michael Hall discovered TOR and gave it the name rapamycin. Hall envisioned that the inhibitors of mammalian TOR were useful in treating autoimmunity, metabolic disorders, cardiovascular disease, and cancer. However, the fact that rapamycin delays the aging process does not mean humanity would be immortal. There will always be new unknown causes of mortality. This is known as post-aging syndrome. One of the main causes of post-aging syndrome is the progress of molecular damage.Aging does not happen by accident. The rate of aging varies depending on an individual and the chances of outliving aging and dying from post-aging syndrome are very low. Post aging syndrome may be identified when a person dies from an unknown disease, unusual variant of a common disease, or rare diseases.

What is Aging?

Aging is the continuation of growth. It is a quasi program: a purposeless and unintended continuation of developmental programs that are not switched off after completion causing diseases. For example, from birth up to adulthood, your blood pressure keeps increasing and the continuation of this trend causes hypertension. Likewise, menopause is the continuation of a reproductive program. Aging pathologies are the continuation of the normal functions of a youthful organism. Therefore, rapamycin affects the same processes in old and young animals because it is a continuation of normal functions.

How Does Rapamycin Work?

Rapamycin prevents geroconversion: this is a conversion from cellular quiescence to senescence. Rapamycin promotes calorie restriction which extends one’s life span. Furthermore, MTOR is involved in aging diseases and rapamycin prevents these diseases in animals. Rapamycin is also involved in genetic manipulations. These manipulations inhibit the TOR pathway and extend the life-span of diverse species.While rapamycin might help address anti-aging, it has not yet addressed the issue of post-aging syndrome. Since aging is an unintended developmental program, scientists cannot claim that with the discovery of rapamycin, humans can be immortal. Rapamycin may only be able to delay aging but mankind will still die for one reason or the other.

Eric Lefkofsky, Jewish American entrepreneur, was born September 2, 1969 in Detroit, Michigan. As Eric grew towards adulthood, his passion for law and business would fuel both his education, and future venture capital.

At age 18, Lefkofsky graduated from Southfield-Lathrup High School to peruse an education at the University of Michigan. While in attendance of the university, he began what would be a long standing business career by selling carpet on campus. Graduating with honors in 1991 at age 22, Eric Lefkofsky furthered education by attending University of Michigan Law School where he received his Juris Doctor, a professional law degree.

Currently known as Chairman of Groupon, and co-founder of Lightbank, a venture capital firm, Lefkofsky was not always such a successful entrepreneur and philanthropist. His original entrepreneurial ventures were smaller and less successful, but in 2001 he helped found InnerWorkings. InnerWorkings, a print procurement company that helps manage costs of printed items such as leaflets, brochures, and magazines for mid-size companies, has witnessed growth and has continued successful stock ratings in the United States. As of 2012, Lefkofsky left the company for bigger and better ventures.

MediaBank, a company that procures media technology, was Lefkofsky’s next business venture with his college friend Brad Keywell. MediaBank in 2007 bought out Datatech, the number one media buying company in the United States. In a $1.5 billion deal, MediaBank became Mediaocean after it merged with Donovan Data Systems.

Possibly one of Lefkofsky’s most successful notable companies is Groupon, an e-commerce marketplace that connects subscribes to local merchants whom offer services and goods at a marketable price. In 2007 however, it was known as The Point. Andrew Mason, founder of The Point, wanted a web based company that would allow people to organize behind causes they found important and achieve a certain goal based on their cause. The company in it’s state only grew a small attraction as people wanted to back and organize for savings and deals. Seeing the opportunity, Eric Lefkofsky funded the company with a cool $1 million. In 2008, the company changed its name to Groupon- a combination of the words group and coupon as homage to what the company now sought to do. As of 2010, Forbes declared Groupon the fastest growing company in history. In 2013, Lefkofsky became CEO of Groupon but later stepped down to take the roll as chairman in 2015. As of 2014 they had a reported income of $3.2 billion and an estimated 10,000 employees.

Beyond business ventures, Eric and his wife Elizabeth Lefkofsky have both been charitable with their earnings. In 2006 they started a charity trust called Lefkofsky Foundation, a private foundation that contributes to smaller organizations, programs, and research that may improve the quality of their surrounding communities.

That includes initiatives that introduce foreign culture, further education, and benefit medical research. They are also participating members in The Giving Pledge, a foundation started by Bill Gates and Warren Buffet to encourage globally influential people of wealth to redistribute some of their earnings to charitable causes.

for more info: